Sangkyu Lee Lab @ibs

Publication archive

Journal Articles

* Co-first authors / # Co-corresponding authors

2026

  1. Tunable TIRF Microscopy: Simultaneous Visualization of Intracellular Dynamics at Multiple Depths.

    Y Jeong, B Choi, T Woo, GW Lee, Y Choi, E-J Park, H Kim, S Lee, JH Kang, J-H Park

    Laser & Photonics Reviews e71952 (2026).

  2. WDR23 prevents bone loss by promoting autophagic degradation of TRAF6 in osteoclastogenesis.

    H-W Park, J Yu, J Yu, J You, YH Kook, J-Y Lee, T Kim, C-H Lee, H-C Chung, J-S Choi, S Lee, JW Rho

    Bone Research 14:98 (2026).

  3. Structural Basis of Lymphangiogenic Receptor VEGFR-3 Activation Mediated by Distinctive Clustering of the Ligand-Receptor Complex.

    R Cho*, J Ahn*, J Yang, DS Lee, G Hong, S Lee#, HM Kim#

    Advanced Science e77728 (2026).

  4. Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus.

    H Kim*, J Lim*, J Kim*, E Ozkan, GH Kim, H Park, MG Park, B Joo, S Lee, KJ Lee, B-K Kaang, CJ Lee, W Koh

    Nature Communications 17:5730 (2026).

  5. Curing the brain: in search for new astrocyte-specific therapies.

    A Verkhratsky#, CJ Lee#, H Chun, C Göritz, T Harkany, J-H Lee, S Lee, M Lindskog, W Koh, J Mulder, M-H Nam , OP Ottersen, M Pekna, M Pekny, A Pękowska, H Ryu, CH Sohn, EO Tretiakov, V Untiet, TJ Viney, W Youn, C Yi, R Zorec, M Yun, E Cheong#, A Nordberg#

    Experimental & Molecular Medicine (2026).

  6. Remodeling Synaptic Connections via Engineered Neuron-Astrocyte Interactions.

    SH Kim*, W Won*, GH Kim*, YH Kook, S Son, DY Kang, MG Park, Y-J Choi, J Shin, KJ Lee#, CJ Lee#, S Lee#

    Nature Communications 17:3490 (2026).

    Scientific American: Scientists can now rewire living brains

2025

  1. A RhoGTPase-effector ensemble governs cell migration behavior.

    H Lee*, S Lee*, Y Seo*, D Kim*, Y Oh, J Jin, B Hyeon, Y Han, H Kim, YJ Lee, H Kim, G Lee#, K-H Cho#, WD Heo#

    Nature Communications 16:9637 (2025).

  2. Deciphering distinct spatial alterations in N-glycan expression profiles in the spinal cord and brain of male rats in a neuropathic pain model.

    HJ Jang*, J Shin*, S Lee, B Lee#, DW Kim

    Cellular & Molecular Biology Letters 30:31 (2025).

  3. Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation.

    J Shin, J Wu, H Park, SI Kim, N Shin, HJ Shin, G Ren, J-a Kim, PTJ Hwang, HW Jun, SY Lee, S Lee, H-G Kim, DW Kim#

    BBA - Molecular Basis of Disease 1871:167737 (2025).

  4. Optogenetic calcium modulation in astrocytes enhances post-stroke recovery in chronic capsular infarct.

    J Cho*, S Lee*, YH Kook, J Park, WD Heo#, CJ Lee#, H-I Kim#

    Science Advances 11:eadn7577 (2025).

2024

  1. Advances in the labelling and selective manipulation of synapses.

    B Timalsina*, S Lee, B-K Kaang#

    Nature Reviews Neuroscience 25, 668-687 (2024).

  2. Real-time visualization of structural dynamics of synapses in live cells in vivo.

    S Son*, K Nagahama*, J Lee*, K Jung*, C Kwak, J Kim, YW Noh, E Kim, S Lee#, H-B Kwon#, WD Heo#

    Nature Methods 21, 353-360 (2024).

  3. Optogenetic STING clustering system through nanobody-fused photoreceptor for innate immune regulation.

    DY Kang*, Y Jang*, H Lee*, J Lee, M Kang, DW Kim, S Lee#, S Lee#

    Sensors and Actuators: B. Chemical 399:134822 (2024).

2023

  1. AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo.

    YH Kook*, H Lee*, J Lee*, Y Jeong, J Rho, WD Heo#, S Lee#

    Molecular Brain 16:73 (2023).

2021

  1. Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody.

    G Jo, J Bae, HJ Hong, A Han, DK Kim, SP Hong, JA Kim, S Lee, GY Koh, HM Kim

    Nature Communications 12:6287 (2021).

2020

  1. Optogenetic control of mRNA localization and translation in live cells.

    NY Kim*, S Lee*#, N Kim, H Park, WD Heo#

    Nature Cell Biology 22, 341 (2020).

  2. Non-invasive optical control of endogenous Ca2+ channels in awake mice.

    S Kim, T Kyung, J-H Chung, N Kim, S Keum, J Lee, H Park, HM Kim, S Lee#, H-S Shin#, WD Heo#

    Nature Communications 11:210 (2020).

2019

  1. Monitoring LC3-or GABARAP-positive autophagic membranes using modified RavZ-based probes

    SW Park, P Jeon, YW Jun, JH Park, SH Lee, S Lee, JA Lee, DJ Jang

    Scientific Reports 9:1 (2019).

  2. Locally activating TrkB receptor generates actin waves and specifies axonal fate.

    D Woo, Y Seo, H Jung, S Kim, N Kim, S-M Park, H Lee, S Lee, K-H Cho, WD Heo

    Cell Chemical Biology 26:1652 (2019).

  3. Intensiometric biosensors visualize the activity of multiple small GTPases in vivo.

    J Kim*, S Lee*, K Jung, WC Oh, N Kim, S Son, Y Jo, H-B Kwon#, WD Heo#

    Nature Communications 10:211 (2019).

2017

  1. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2.

    H Park*, NY Kim*, S Lee, N Kim, WD Heo

    Nature Communications 8:30 (2017).

2016

  1. Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking.

    MK Nguyen, CY Kim, JM Kim, BO Park, S Lee, H Park, WD Heo

    Nature Chemical Biology 12, 431 (2016).

2015

  1. Optogenetic control of endogenous Ca2+ channels in vivo.

    T Kyung*, S Lee*, JE Kim, T Cho, H Park, Y-M Jeong, D Kim, A Shin, S Kim, J Baek, J Kim, NY Kim, D Woo, S Chae, C-H Kim, H-S Shin, Y-M Han#, D Kim#, WD Heo#

    Nature Biotechnology 33, 1092 (2015).

    Cover Article. This article was recommended by the faculty of 1000.

2014

  1. Light-inducible receptor tyrosine kinases that regulate neurotrophin signaling.

    K-Y Chang*, D Woo*, H Jung, S Lee, S Kim, J Won, T Kyung, H Park, N Kim, HW Yang, J-Y Park, EM Hwang, WD Heo

    Nature Communications 5:4057 (2014).

  2. Reversible protein inactivation by optogenetic trapping in cells.

    S Lee*, H Park*, T Kyung, NY Kim, S Kim, J Kim, WD Heo

    Nature Methods 11, 633 (2014).

    This article was highlighted by Nature Methods.

2013

  1. Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.

    H-W Lee, T Kyung, J Yoo, T Kim, C Chung, JY Ryu, H Lee, K Park, S Lee, WD Jones, D-S Lim, C Hyeon, WD Heo, T-Y Yoon

    Nature Communications 4:1505 (2013).

2012

  1. Inducible biosynthetic nanoscaffolds as recruitment platforms for detecting molecular target interactions inside living cells.

    S Lee*, JS Ha*, SG Lee, TK Kim

    J. Am. Chem. Soc. 134, 11346 (2012).

  2. Cooperative activation of PI3K by Ras and Rho family small GTPases.

    HW Yang, MK Shin, S Lee, WS Park, J-R Kim, K-H Cho, T Meyer, WD Heo

    Molecular Cell 47, 281 (2012).

2011

  1. Small-molecule-based nanoassemblies as inducible nanoprobes for monitoring dynamic molecular interactions inside live cells.

    S Lee, KH Lee, JS Ha, SG Lee, TK Kim

    Angew. Chem. Int. Ed. Engl. 50, 8709-8713 (2011).

2010

  1. Visualizing dynamic interaction between calmodulin and calmodulin-related kinases via a monitoring method in live mammalian cells.

    KH Lee, S Lee, WY Lee, HW Yang, WD Heo

    Proc. Natl. Acad. Sci. USA 107, 3412-3417 (2010).

Book Chapters

2016

  1. Protein inactivation by optogenetic trapping in living cells.

    H Park, S Lee, WD Heo

    Methods Mol. Biol. 1408, 363-376 (2016).